IgG autoantibodies play a role
in CIDP1,2

The exact pathophysiology of CIDP is complex and not completely understood, but our knowledge of its mechanisms is expanding.1,3

Evidence suggests that IgG autoantibodies may be key to our understanding.1,2

CIDP=chronic inflammatory demyelinating polyneuropathy;
IgG=immunoglobulin G.

Discover how IgG autoantibodies can trigger damage in CIDP

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CIDP=chronic inflammatory demyelinating polyneuropathy; IgG=immunoglobulin G.

The role of IgG autoantibodies in CIDP

In patients with CIDP, the binding activity of autoantibodies, including IgG autoantibodies, to the myelin sheath may result in demyelination, subsequent nerve damage, and symptom expression.1,3,4

Infiltration of IgG autoantibodies

Activated T cells trigger inflammatory mediators (cytokines and chemokines) to breach the blood-nerve barrier, facilitating the passage of autoantibodies, including IgG autoantibodies.1,2,4

Inflirtation of IgG
Depiction of the two ways that IgG autoantibodies have been shown to contribute to disease progress in CIDP.

1. Activated T cell
2. Cytokines/chemokines
3. Plasma cell
4. IgG autoantibodies

5. Blood-nerve barrier

Demyelination due to IgG autoantibodies

IgG autoantibodies bind to the myelin sheath, where they either recruit macrophages directly or activate the complement pathway, which may result in myelin damage.1-4

Inflirtation of IgG
Depiction of IgG autoantibodies crossing the blood-nerve barrier, along with other inflammatory mediators.

1. IgG autoantibodies
2. Macrophage
3. Fc receptor
4. Myelin sheath

5. Complement proteins

CIDP=chronic inflammatory demyelinating polyneuropathy; Fc=fragment, crystallized;
IgG=immunoglobulin G.

References: 1. Mathey EK et al. J Neurol Neurosurg Psychiatry. 2015;86:973-985. doi:10.1136/jnnp-2014-309697 2. Querol LA et al. Neurotherapeutics. 2022;19(3):864-873. doi:10.1007/s13311-022-01221-y 3. Dziadkowiak E et al. Int J Mol Sci. 2022;23:2-13. doi.org/10.3390/ijms23010179 4. Koike H et al. Neurol Ther. 2020;9:213-227. doi.org/10.1007/s40120-020-00190-8